This profile of the Center for Reducing Health Disparities at Case Western Reserve University and the MetroHealth hospital system is based on interviews conducted in winter 2015 with Sherrie Williams, MD, MHS, and Daryl Thornton, MD, MPH, both pulmonary and critical care specialists at MetroHealth. Dr. Williams is president of the medical staff at MetroHealth and an associate professor at Case Western Reserve University School of Medicine. Dr. Thornton is co-director of the Center for Reducing Health Disparities. He is also director of MetroHealth’s medical intensive care unit and an associate professor at Case Western Reserve University School of Medicine. This brief is a “snapshot in time” intended to illustrate how a safety net hospital and its partners used research and other evidence to help inform program development. It is not intended to be a comprehensive analysis of a particular program or partnership.