Comparison of Large vs. Small Panel Biomarker Capture Rates for NCCN Guidelines & Clinical Trials
Understand the extent to which commercially-available small and large NGS panels capture biomarkers recommended in NCCN guidelines and/or required for clinical trial eligibility.
Key Activities
Research studies exploring biomarker capture in small and large NGS panels across 8 common tumor types. Results indicate that larger panels are more likely to assess all NCCN-recommended biomarkers and assess twice as many biomarkers that are required for clinical trial eligibility than targeted panels. However, larger panels do not always assess the full range of NCCN-recommended biomarkers, and they assess the required biomarkers for clinical trials with varying efficiency by tumor type.