This project is funded under the Robert Wood Johnson Foundation’s research program, “Health Data for Action (HD4A),” which makes valuable data from unique data owners available to researchers to answer important research questions. The goal of the study is to inform evidence-based guidelines and practice to prevent and/or manage immediate and long-term effects of cystectomy surgery in bladder cancer patients. Using Geisinger data, the study seeks to review the Controlling Nutritional Status (CONUT) scoring system to evaluate patient-specific risk factors that can be incorporated into clinical practice for pre-operative risk assessment and decision-making when radical cystectomy is being considered for treatment of muscle invasive bladder cancer. Specifically, the study will 1) investigate the prognostic value of CONUT score in the development of perioperative/postoperative complications and mortality, including in-hospital and 30/90-day mortality, cancer specific, and all-cause mortality, and 2) model the accuracy of nutritional risk prognostication tools for short- and long-term prognosis and rate of perioperative complications. Tools will include CONUT, prognostic Index of Nutrition (PNI), Nutrition Risk Index (NRI), albumin and BMI. Deliverables will include a project work plan and final narrative report. The researchers will also produce paper(s) suitable for publication and present findings at national research meetings and to other stakeholder audiences as appropriate, including policymakers at the federal, state, and local levels and other key stakeholders, as part of the deliverables for this grant.

Grant #78966
Grantee Organization: University Hospitals Cleveland Medical Center
Grantee period: 12/1/2021– 11/30/2022

Principal Investigators:

Laura Bukavina headshot

Laura Bukavina, M.D.

Urologic Oncology Fellow - Fox Chase Cancer Center

Laura Bukavina, MD is an expert in patient centered outcomes in urologic oncology and translational research i... Read Bio


Adam Calaway, M.D., M.P.H.

Assistant Professor - University Hospitals/Case Western Reserve University School of Medicine

Adam C Calaway is an Assistant Professor of Urology at University Hospitals/Case Western Reserve University Sc... Read Bio