Dr. Wu is Fred and Juliet Soper Professor of Health Policy and Management in the Johns Hopkins Bloomberg School of Public Health, with joint appointments in Epidemiology, International Health, Medicine, Surgery, and the Carey Business School, and Director of the Johns Hopkins Center for Health Services & Outcomes Research. His research and teaching focus on patient outcomes and quality of care. He was the first to measure the quality of life impact of antiretroviral therapy in HIV clinical trials, and developed widely used patient reported outcome measures for chronic disease. He was co-founder and director of the outcomes research committee of the NIH AIDS Clinical Trials Group, and President of the International Society for Quality of Life. He is a thought leader in the integration of PROs into electronic health records, and their use for comparative effectiveness research. He is co-PI of the RWJF Accelerating Collaborations for Equity program, and is director of Baltimore CONNECT, Inc (501c3), a network of community-based social service organizations.

He has studied patient safety since 1988 and directs Strategic Collaborations for the Armstrong Institute for Patient Safety. He was a member of the Institute of Medicine committee on preventing medication errors, and Senior Adviser for Patient Safety to WHO in Geneva. He is editor-in-chief of Journal of Patient Safety and Risk Management (Sage) and has authored over 500 peer-reviewed publications and two books. He led the AHRQ T-32 NRSA Predoctoral Training Grant in Health Services Research, and the PhD program at Johns Hopkins. He leads the Masters of Applied Science in Patient Safety and Healthcare Quality. He has mentored over 100 graduate advisees and post-doctoral fellows in health services research. He received the 2016 Stebbins Medal for contributions to the educational programs in the Bloomberg School, and the 2019 AHRQ John M. Eisenberg Excellence in Mentorship Award.

Dr. Wu received BA and MD degrees from Cornell University, and completed Internal Medicine residency at the Mount Sinai Hospital and UC San Diego. He was a Robert Wood Johnson Clinical Scholar at UCSF and received an MPH from UC Berkeley. He maintains a clinical practice in general internal medicine.