This publication reviews multiple case studies using various research data collection methods, comparing the advantages and disadvantages of the different methods in the time of technological advancement.

Background: Primary data collection is a critical activity in clinical research. Even with significant advances in technical capabilities, clear benefits of use, and even user preferences for using electronic systems for collecting primary data, paper-based data collection is still common in clinical research settings. However, with recent developments in both clinical research and tablet computer technology, the comparative advantages and disadvantages of data collection methods should be determined.

Objective: To describe case studies using multiple methods of data collection, including next-generation tablets, and consider their various advantages and disadvantages.

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